Pol III Holoenzyme is a big molecule that consists of 10 different subunits. Three subunits alpha, epsilon and theta form the core and there are 2 cores in a Pol III Holo enzyme complex that linked by tau subunit. Each core is responsible for leading and lagging synthesis. The gamma complex (clamp loader) is composed of gamma, delta, delta prime, chi and psi subunits; take in charge in loading beta clamp onto primed DNA. The complex consist of two cores and the gamma complex is called as Polymerase III*. When beta clamp is added to each Continue Reading →