What is DNA polymerase switch?
DNA polymerase switch is an activity whereby a polymerase is replaced by the other polymerase. There are 5 distinct DNA polymerases in the E. coli cell: Pol I, Pol II, Pol III, Pol IV, Pol V, each has different roles in genomic maintenance and evolution. Among these 5 polymerases, DNA Pol III Holoenzyme (Pol III HE) is a primary enzyme for DNA replication that can synthesize new strand with very high processivity (more than 50 kb per binding event) and high speed (about 1kb per second). However, Pol III HE is Continue Reading →