DNA replication origin

Replication origin is the sequences where replication started. Usually, DNA structure is the double helix, to be used as the template for replication, the duplex parental strands must be opened, by breaking hydrogen bonds between two strands. Therefore, usually, replication origin is the A-T rich sequences, as A-T base pairs contain fewer hydrogen bond than G-C base pairs. In E. coli, there is only a single origin for genome replication called OriC (232 – 245 bp). The initiator proteins bind this sequence and start replication in Continue Reading →